The Effect of Code Obfuscation on Authorship Attribution of Binary Computer Files

In many forensic investigations, questions linger regarding the identity of the authors of the software specimen. Research has identified methods for the attribution of binary files that have not been obfuscated, but a significant percentage of malicious software has been obfuscated in an effort to hide both the details of its origin and its true intent. Little research has been done around analyzing obfuscated code for attribution. In part, the reason for this gap in the research is that deobfuscation of an unknown program is a challenging task. Further, the additional transformation of the executable file introduced by the obfuscator modifies or removes features from the original executable that would have been used in the author attribution process. Existing research has demonstrated good success in attributing the authorship of an executable file of unknown provenance using methods based on static analysis of the specimen file. With the addition of file obfuscation, static analysis of files becomes difficult, time consuming, and in some cases, may lead to inaccurate findings. This paper presents a novel process for authorship attribution using dynamic analysis methods. A software emulated system was fully instrumented to become a test harness for a specimen of unknown provenance, allowing for supervised control, monitoring, and trace data collection during execution. This trace data was used as input into a supervised machine learning algorithm trained to identify stylometric differences in the specimen under test and provide predictions on who wrote the specimen. The specimen files were also analyzed for authorship using static analysis methods to compare prediction accuracies with prediction accuracies gathered from this new, dynamic analysis based method. Experiments indicate that this new method can provide better accuracy of author attribution for files of unknown provenance, especially in the case where the specimen file has been obfuscated

The transcriptional landscape of Shh medulloblastoma

© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Furthermore, we discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several loss-of-function fusions in tumor suppressor genes PTCH1, SUFU and NCOR1. Molecular convergence on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma and open up opportunities for therapeutic intervention.info:eu-repo/semantics/publishedVersio

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage 5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL 9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage 3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES +KI67 + unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB

Auditory-visual scenes for hearing research

While experimentation with synthetic stimuli in abstracted listening situations has a long standing and successful history in hearing research, an increased interest exists on closing the remaining gap towards real-life listening by replicating situations with high ecological validity in the lab. This is important for understanding the underlying auditory mechanisms and their relevance in real-life situations as well as for developing and evaluating increasingly sophisticated algorithms for hearing assistance. A range of - classical'stimuli and paradigms have evolved to de-facto standards in psychoacoustics, which are simplistic and can be easily reproduced across laboratories. While they ideally allow for across laboratory comparisons and reproducible research, they, however, lack the acoustic stimulus complexity and the availability of visual information as observed in everyday life communication and listening situations. This contribution aims to provide and establish an extendable set of complex auditory-visual scenes for hearing research that allow for ecologically valid testing in realistic scenes while also supporting reproducibility and comparability of scientific results. Three virtual environments are provided (underground station, pub, living room), consisting of a detailed visual model, an acoustic geometry model with acoustic surface properties as well as a set of acoustic measurements in the respective real-world environments. The current data set enables i) audio'visual research in a reproducible set of environments, ii) comparison of room acoustic simulation methods with - ground truth acoustic measurements, iii) a condensation point for future extensions and contributions for developments towards standardized test cases for ecologically valid hearing research in complex scenes

Auditory-visual scenes for hearing research

While experimentation with synthetic stimuli in abstracted listening situations has a long standing and successful history in hearing research, an increased interest exists on closing the remaining gap towards real-life listening by replicating situations with high ecological validity in the lab. This is important for understanding the underlying auditory mechanisms and their relevance in real-life situations as well as for developing and evaluating increasingly sophisticated algorithms for hearing assistance. A range of ‘classical’ stimuli and paradigms have evolved to de-facto standards in psychoacoustics, which are simplistic and can be easily reproduced across laboratories. While they ideally allow for across laboratory comparisons and reproducible research, they, however, lack the acoustic stimulus complexity and the availability of visual information as observed in everyday life communication and listening situations. This contribution aims to provide and establish an extendable set of complex auditory-visual scenes for hearing research that allow for ecologically valid testing in realistic scenes while also supporting reproducibility and comparability of scientific results. Three virtual environments are provided (underground station, pub, living room), consisting of a detailed visual model, an acoustic geometry model with acoustic surface properties as well as a set of acoustic measurements in the respective real-world environments. The current data set enables i) audio–visual research in a reproducible set of environments, ii) comparison of room acoustic simulation methods with “ground truth” acoustic measurements, iii) a condensation point for future extensions and contributions for developments towards standardized test cases for ecologically valid hearing research in complex scenes

The transcriptional landscape of Shh medulloblastoma

Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the cAMP dependent pathway (GNAS, PRKAR1A) which converge on GLI2 activity and show that 18% of tumors have a genetic event that directly targets the abundance and/or stability of MYCN. Furthermore, we discover an extensive network of fusions in focally amplified regions encompassing GLI2, and several loss-of-function fusions in tumor suppressor genes PTCH1, SUFU and NCOR1. Molecular convergence on a subset of genes by nucleotide variants, copy number aberrations, and gene fusions highlight the key roles of specific pathways in the pathogenesis of Sonic hedgehog medulloblastoma and open up opportunities for therapeutic intervention

Failure of human rhombic lip differentiation underlies medulloblastoma formation

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage 5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL 9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage 3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES +KI67 + unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB